If you have an eBay store you can do this:
To turn on your Store vacation settings:
Click the Messages tab in My eBay.
Select the Change settings link on the top right side of the page.
In the Store vacation settings section, select Turn ON.
If you'd like to hide your fixed price listings and prevent buyers from making purchases from them while you're away, select Hide and block purchases from my fixed price listings.
If you'd like buyers to see a return date, select Display a return date, and enter a date in the box provided.
In the Message to display on your storefront section, edit the default text displayed in the textbox if you would like to customize it.
Click the Apply button.
go to here for more information http://pages.ebay.com/help/sell/plac...-vacation.html
Otherwise if you don't have an eBay store make sure the listings end after you come back from vacation, you can do this by setting a scheduled start time when making a listing.
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